https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2026.0016
Announcing a new article publication for
Cardiovascular Innovations and Applications journal. Cardiovascular disease (CVD) is a leading cause of mortality among cancer survivors, yet the contributions of socioeconomic, lifestyle, and clinical factors to CVD remain unexplored.
This study was aimed at examining associations between these factors and prevalent CVD in adults with prior cancer and comparing them with those in a matched non-cancer cohort.
97,648 adults from the National Health and Nutrition Examination Survey were analyzed. Associations of socioeconomic, lifestyle, and clinical factors with a composite endpoint of five self-reported cardiovascular events were assessed with multivariable logistic regression. Interaction analyses assessed differences by cancer status, and sensitivity analyses examined individual cardiovascular outcomes.
5584 cancer survivors and 9933 matched participants without cancer were included. Age, sex, unemployment, low income, current smoking, obesity, diabetes, hypertension, and hypercholesterolemia were associated with elevated odds of CVD prevalence in both groups. Among only cancer survivors, an absence of private insurance, or the presence of food insecurity or low educational attainment, was also independently associated with CVD prevalence. Sensitivity analyses indicated broadly consistent results across individual outcomes.
Socioeconomic, lifestyle, and clinical factors were associated with prevalent CVD among cancer survivors, with socioeconomic disadvantage contributing to disparities in CVD burden. Because the outcomes were self-reported, and the study was cross-sectional, the findings should be interpreted as associative rather than causal or predictive.
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Ao Shi, Yixiao Lu and Jianfeng Shi et al. Socioeconomic, Lifestyle, and Clinical Factors Associated with Cardiovascular Events in the U.S. Cancer Population.
CVIA. 2026. Vol. 11(1). DOI: 10.15212/CVIA.2026.0016