Understanding Vascular Toxicity of Indigo Naturalis in Anti-Inflammatory Applications: Mendelian Randomization and Co-localization Study
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Understanding Vascular Toxicity of Indigo Naturalis in Anti-Inflammatory Applications: Mendelian Randomization and Co-localization Study

30/12/2025 Compuscript Ltd
https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2025-0155
Announcing a new article publication for BIO Integration journal. Indigo naturalis (IN), a traditional Chinese herbal medicine, shows promising potential for treating autoimmune inflammatory diseases. However, its clinical translation and application are being limited by concerns regarding vascular toxicity.
Mendelian randomization (MR) and colocalization analyses were conducted to systematically investigate the target-specific vascular risks associated with IN.
Causal associations were identified between four targets of IN and multiple vascular disorders, including deep vein thrombosis (DVT) (OR = 1.001, 95% CI = 1.003-1.000, P = 0.008), among others. Notably, urate was identified as a mediator between IN and DVT, exhibiting a mild mediation effect (7.3%, P = 0.048).
For the first time, the causal effects of IN on vascular toxicity were demonstrated using MR. This study provides insights into the safety implications of IN for anti-inflammatory applications, which would facilitate evidence-based research on IN and its clinical translation.
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BIO Integration is fully open access journal which will allow for the rapid dissemination of multidisciplinary views driving the progress of modern medicine.

As part of its mandate to help bring interesting work and knowledge from around the world to a wider audience, BIOI will actively support authors through open access publishing and through waiving author fees in its first years. Also, publication support for authors whose first language is not English will be offered in areas such as manuscript development, English language editing and artwork assistance.

Please visit www.bio-integration.org to learn more about the journal.
Editorial Board: https://bio-integration.org/editorial-board/

BIOI is available on the ScienceOpen platform (https://www.scienceopen.com/search#collection/55f45bac-fd64-431c-9fe7-50fd6a7f8781).

Submissions may be made using ScholarOne (https://mc04.manuscriptcentral.com/bioi).
There are no author submission or article processing fees.

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ISSN 2712-0074
eISSN 2712-0082

Jie Liu, Chengjian Liu and Haitao Xiao et al. Understanding Vascular Toxicity of Indigo Naturalis in Anti-Inflammatory Applications: Mendelian Randomization and Co-localization Study. BIOI. 2025. Vol. 6(1). DOI: 10.15212/bioi-2025-0155
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Jie Liu, Chengjian Liu and Haitao Xiao et al. Understanding Vascular Toxicity of Indigo Naturalis in Anti-Inflammatory Applications: Mendelian Randomization and Co-localization Study. BIOI. 2025. Vol. 6(1). DOI: 10.15212/bioi-2025-0155
30/12/2025 Compuscript Ltd
Regions: Europe, Ireland
Keywords: Health, Medical

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