Schwannomas are relatively common in the head and neck but rare in the nasal cavity and paranasal sinuses. Ancient schwannoma is an uncommon subtype characterized by degenerative changes—cystic change, nuclear atypia, hemorrhage, and hyalinization—that can make it masquerade as a more aggressive neoplasm. In this case, a 42-year-old woman presented with 9 months of left nasal obstruction and epistaxis; imaging revealed a large soft-tissue mass (approximately 5.8 cm × 3.8 cm on CT) nearly obliterating the left nasal cavity with bony expansion and remodeling but no intraorbital invasion.

Histopathology showed Antoni A and B areas with hemorrhage, hyalinization, thick-walled dilated vessels, nuclear atypia, and hemosiderin deposition; immunohistochemistry was strongly and diffusely positive for S-100 and negative for SMA, CD34, and CD10, with a Ki-67 index below 5%, consistent with ancient schwannoma. The tumor was completely excised via a transnasal approach, and the patient recovered well with no signs of recurrence at 2 months. The authors note that histopathology is the diagnostic gold standard and complete surgical excision offers an excellent prognosis.

The work titled “Ancient Schwannoma in the Nasal Cavity—A Rare Case Report With Brief Literature Review”, was published on Eye & ENT Research (published on July 22, 2026).
DOI:10.1002/eer3.70051