A comprehensive new review is bringing together the latest advances in Ménière’s disease, offering a clearer picture of the biological mechanisms that may drive this complex inner ear disorder while highlighting new directions for diagnosis, disease modeling, and treatment. The article proposes that the endolymphatic sac, a structure involved in maintaining the inner ear environment, may represent the central site where multiple disease-triggering factors converge, providing a unifying explanation for the diverse symptoms experienced by patients.
Ménière’s disease is a chronic condition characterized by recurring episodes of vertigo, fluctuating hearing loss, tinnitus, and a feeling of fullness in the ear. Although the disease has been recognized for more than a century, its underlying cause has remained uncertain. The review explains that rather than arising from a single mechanism, the disorder is likely influenced by a combination of genetic susceptibility, immune dysfunction, viral infection, inflammation, impaired ion regulation, and abnormalities in inner ear fluid balance. These diverse factors may ultimately disrupt the function of the endolymphatic sac, leading to the development of endolymphatic hydrops, the hallmark pathological feature of the disease.
The article also examines the strengths and limitations of current animal models, noting that while existing models have improved understanding of disease mechanisms, none fully reproduces the fluctuating symptoms seen in patients. The review suggests that combining surgical, biological, and genetic approaches may produce more representative models and accelerate the development of new therapies.
Rapid advances in multi-omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, are also transforming the field. These approaches have identified molecular pathways linked to immune activation, oxidative stress, abnormal ion transport, extracellular matrix remodeling, and altered nerve signaling. Together, these findings are helping to identify potential biomarkers that could improve diagnosis while revealing new therapeutic targets.
The review highlights growing evidence that the immune system plays an important role in disease progression. Inflammatory signaling, allergic responses, viral infections, and even changes in the inner ear microbiome may contribute to damage within the endolymphatic sac. At the same time, genetic discoveries are uncovering inherited variants associated with both familial and sporadic forms of the disease, further supporting the involvement of pathways controlling fluid regulation and sensory cell function.
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Reference
Siyuan Liu, Yanshi Li, Yuting Zhang, Yuxiao Zheng, Chen Jin, Lin Chen, Guohua Hu, Wenqi Zuo, Research progress on the mechanisms and animal models of Ménière’s disease, Genes & Diseases, Volume 13, Issue 5, 2026, 102022, https://doi.org/10.1016/j.gendis.2025.102022

Funding
Natural Science Foundation of Chongqing, China CSTB2024NSCQ-MSX1014