A new review article highlights a rapidly emerging frontier in oncology: the dynamic and influential relationship between nerves and tumors. This evolving field is reshaping how scientists and clinicians understand cancer progression, revealing that tumors are not isolated masses but part of a complex, interactive tumor microenvironment that includes neural networks alongside immune and stromal components.
The article underscores how nerve–tumor interactions play a critical role in shaping disease behavior. Signals originating from the peripheral nervous system can directly influence cancer cell proliferation, drive metastasis, and contribute to treatment resistance. At the same time, tumors actively remodel nearby nerves, creating a bidirectional communication loop that accelerates disease progression.
Three major processes define this interaction: perineural invasion, axonogenesis, and neurogenesis. These mechanisms collectively enable tumors to invade nerve structures, stimulate the growth of new nerve fibers, and even generate entirely new neural connections. Such processes are strongly associated with more aggressive disease and poorer outcomes across multiple cancer types.
Beyond direct tumor effects, the review emphasizes the broader impact of neural signaling within the tumor microenvironment. Neurotransmitters and neuropeptides released by nerves influence immune cells, stromal cells, and blood vessels, reshaping the local environment to favor tumor survival and immune evasion. This intricate neuro-immune crosstalk represents a crucial but underexplored dimension of cancer biology.
Importantly, these discoveries are opening new opportunities for therapeutic innovation. Strategies that disrupt nerve signaling, modulate neurotransmitter pathways, or target nerve growth factors are emerging as promising approaches. Some existing neuroactive drugs are already being explored for their ability to interfere with tumor-supporting neural activity, while nerve-targeted interventions may also help alleviate cancer-associated pain.
Advances in technologies such as single-cell sequencing, spatial transcriptomics, and neural tracing are accelerating progress in this field, allowing researchers to map and manipulate nerve–tumor interactions with unprecedented precision. These tools are expected to drive the next wave of discoveries and clinical applications.
Overall, the review positions the nerve–tumor axis as a transformative concept in modern oncology, with the potential to redefine treatment strategies and improve patient outcomes by targeting an often-overlooked component of cancer biology.
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Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis is placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.
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Reference
Liangzhan Sun, Xia Li, Yaxuan Wang, Jingxuan Wang, Renrui Xie, Ningyi Zhang, Zemin Zhang, Understanding nerve–tumor interactions: From basic biology to therapeutic innovation, Genes & Diseases, Volume 13, Issue 4, 2026, 101955, https://doi.org/10.1016/j.gendis.2025.101955

Funding
Chongqing Key Talent Project (China) X9-1358
Chongqing Medical University Start-up Research Funding (China) J0325001