A Review of Clinical Trials in Drug Discovery and Development
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A Review of Clinical Trials in Drug Discovery and Development

12/03/2026 Compuscript Ltd
https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2025-0198
Announcing a new article publication for BIO Integration journal. Clinical trials bridge basic research and clinical application, serving as essential steps in drug development. This review examines clinical trial phases (Phase I [safety assessment], Phase II [efficacy evaluation], Phase III [large-scale validation], and Phase IV [post-marketing surveillance]), highlighting the distinct characteristics and interconnections. Major challenges are identified, including ethical compliance, participant recruitment, and ensuring diversity and representativeness in trial populations, while proposing evidence-based mitigation strategies. To address these challenges, innovative technologies, such as artificial intelligence, big data analytics, and digital health tools, are transforming trial design and implementation, enhancing efficiency and data quality. Looking forward, the review explores how emerging therapies, including gene therapy and immunotherapy, are reshaping trial design requirements and emphasizes the growing importance of regulatory harmonization and global collaboration. Clinical trials remain central to advancing innovative drug development and improving patient outcomes.
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BIO Integration is fully open access journal which will allow for the rapid dissemination of multidisciplinary views driving the progress of modern medicine.

As part of its mandate to help bring interesting work and knowledge from around the world to a wider audience, BIOI will actively support authors through open access publishing and through waiving author fees in its first years. Also, publication support for authors whose first language is not English will be offered in areas such as manuscript development, English language editing and artwork assistance.

Please visit www.bio-integration.org to learn more about the journal.
Editorial Board: https://bio-integration.org/editorial-board/

BIOI is available on the ScienceOpen platform (https://www.scienceopen.com/search#collection/55f45bac-fd64-431c-9fe7-50fd6a7f8781).

Submissions may be made using ScholarOne (https://mc04.manuscriptcentral.com/bioi).
There are no author submission or article processing fees.

Follow BIOI on Twitter @JournalBio; Facebook (https://www.facebook.com/BIO-Integration-Journal-108140854107716/) and LinkedIn (https://www.linkedin.com/company/bio-integration-journal/).

ISSN 2712-0074
eISSN 2712-0082

Tianyang Wang, Ming Liu and Benji Peng et al. From Bench-to-Bedside: A Review of Clinical Trials in Drug Discovery and Development. BIOI. 2026. Vol. 7(1). DOI: 10.15212/bioi-2025-0198
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Tianyang Wang, Ming Liu and Benji Peng et al. From Bench-to-Bedside: A Review of Clinical Trials in Drug Discovery and Development. BIOI. 2026. Vol. 7(1). DOI: 10.15212/bioi-2025-0198
12/03/2026 Compuscript Ltd
Regions: Europe, Ireland
Keywords: Health, Medical

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