Low-intensity Pulsed Ultrasound: A Promising Strategy for the Treatment of POI
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Low-intensity Pulsed Ultrasound: A Promising Strategy for the Treatment of POI

03/02/2026 Compuscript Ltd
https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2025-0131
Announcing a new article publication for BIO Integration journal. Premature ovarian insufficiency (POI) is a complex endocrine disorder characterized by premature depletion of ovarian follicles, and resulting in ovarian failure and decreased fertility. Conventional hormone replacement therapy (HRT) alleviates menopausal symptoms but carries potential risks, such as breast malignancies, and does not restore ovarian endocrine function. As a noninvasive physical therapy, low-intensity pulsed ultrasound (LIPUS) regulates cell proliferation, apoptosis, inflammation, and angiogenesis through mechanical stress, cavitation effects, and microstreaming, thus providing a novel therapeutic avenue for POI. This article systematically analyzes recent advances in the application of LIPUS in POI, demonstrating its mechanism of regulating ovarian function. The combination of LIPUS with other therapies for POI and discuss prospects for LIPUS-based treatments is also analyzed.
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BIO Integration is fully open access journal which will allow for the rapid dissemination of multidisciplinary views driving the progress of modern medicine.

As part of its mandate to help bring interesting work and knowledge from around the world to a wider audience, BIOI will actively support authors through open access publishing and through waiving author fees in its first years. Also, publication support for authors whose first language is not English will be offered in areas such as manuscript development, English language editing and artwork assistance.

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ISSN 2712-0074
eISSN 2712-0082

Zenan Zhang, Chenke Kuang and Zhili Guo et al. Low-intensity Pulsed Ultrasound: A Promising Strategy for the Treatment of POI. BIOI. 2026. Vol. 7(1). DOI: 10.15212/bioi-2025-0131
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Zenan Zhang, Chenke Kuang and Zhili Guo et al. Low-intensity Pulsed Ultrasound: A Promising Strategy for the Treatment of POI. BIOI. 2026. Vol. 7(1). DOI: 10.15212/bioi-2025-0131
03/02/2026 Compuscript Ltd
Regions: Europe, Ireland, North America, United States
Keywords: Health, Medical

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