iPSC modification strategies to induce immune tolerance
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iPSC modification strategies to induce immune tolerance

31/10/2025 Frontiers Journals
Human pluripotent stem cells (hPSCs) hold great promise in regenerative medicine. However, immune rejections remain one of the major obstacles to stem cell therapy. Though conventional immunosuppressants are available in clinics, the side effects prevent the wide application of hPSCs derivatives, compromising both survival rate and quality of life. In recent years, a myriad of strategies aimed at inducing immune tolerance specifically by engineering stem cells has been introduced to society. A team led by Dr. Kai Wang from Department of Physiology and Pathophysiology, Peking University summarized the scheme of hPSCs immune tolerance induction in allo-transplantation. This includes human leukocyte antigen (HLA) editing to avoid T cell recognition and NK activation. Immune cloak strategy is the focus of this review, with emphasis on the overexpression of immune checkpoints and the blocking of immune cytotoxic pathways. Nevertheless, co-transplantation with mesenchymal stem cells (MSCs) and enhanced MSCs confers immune privilege to engraftments. In addition, this review endeavors to deliberate upon the safety and limitations associated with this promising and potential therapeutic modality.
DOI: 10.1093/lifemedi/lnaf016
https://journal.hep.com.cn/lifemed/EN/10.1093/lifemedi/lnaf016
iPSC modification strategies to induce immune tolerance
Life Medicine ›› 2025, Vol. 4 ›› Issue (3) : lnaf016 DOI: 10.1093/lifemedi/lnaf016
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31/10/2025 Frontiers Journals
Regions: Asia, China, Europe, United Kingdom
Keywords: Science, Life Sciences

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