https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2025-0049
Announcing a new article publication for
BIO Integration journal. As a mechanical wave capable of transmitting thermal and mechanical energy, ultrasound has emerged as a pivotal tool in regenerative medicine due to its non-invasive nature. Low-intensity pulsed ultrasound (LIPUS), a mechanoregulatory technique independent of thermal effects, delivers controlled mechanical stimuli to activate endogenous mechanotransduction pathways, such as ion channels, transmembrane proteins, and cytoskeleton-mediated signaling cascades. These pathways regulate critical cellular processes, such as proliferation, differentiation, and apoptosis, positioning LIPUS as a promising modality for targeted modulation of cell fate. Preclinical and clinical studies have demonstrated the therapeutic efficacy of LIPUS across diverse applications, including bone repair, neural regeneration, and soft tissue rehabilitation. However, optimizing stimulation parameters and advancing clinical translation remain key challenges. This article summarizes the central role of LIPUS in promoting tissue regeneration through non-thermal regulation of cellular homeostasis and explores strategies to accelerate clinical adoption of LIPUS. By integrating mechanistic insights with translational perspectives, this review provides a roadmap for advancing LIPUS-driven regenerative medicine in the era of precision bioengineering.
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BIO Integration is fully open access journal which will allow for the rapid dissemination of multidisciplinary views driving the progress of modern medicine.
As part of its mandate to help bring interesting work and knowledge from around the world to a wider audience,
BIOI will actively support authors through open access publishing and through waiving author fees in its first years. Also, publication support for authors whose first language is not English will be offered in areas such as manuscript development, English language editing and artwork assistance.
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www.bio-integration.org to learn more about the journal.
Editorial Board: https://bio-integration.org/editorial-board/
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https://www.scienceopen.com/search#collection/55f45bac-fd64-431c-9fe7-50fd6a7f8781).
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ISSN 2712-0074
eISSN 2712-0082
Lingling Lei, Qing Zhang and Meng Du et al. Mechanoregulation of Cell Fate by Low-intensity Pulsed Ultrasound: Mechanisms and Advances in Regenerative Medicine.
BIOI. 2025. Vol. 6(1). DOI: 10.15212/bioi-2025-0049
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