https://doi.org/10.1016/j.apsb.2025.04.007
This new article publication from
Acta Pharmaceutica Sinica B, discusses how a photodynamic nanohybrid system reverses hypoxia and augments anti-primary and metastatic tumor efficacy of immunotherapy.
Photodynamic immunotherapy is a promising strategy for cancer treatment. However, the dysfunctional tumor vasculature results in tumor hypoxia and the low efficiency of drug delivery, which in turn restricts the anticancer effect of photodynamic immunotherapy.
The authors of this article designed photosensitive lipid nanoparticles. The synthesized PFBT@Rox Lip nanoparticles could produce type I/II reactive oxygen species (ROS) by electron or energy transfer through PFBT under light irradiation. Moreover, this nanosystem could alleviate tumor hypoxia and promote vascular normalization through Roxadustat. Upon irradiation with white light, the ROS produced by PFBT@Rox Lip nanoparticles
in situ dysregulated calcium homeostasis and triggered endoplasmic reticulum stress, which further promoted the release of damage-associated molecular patterns, enhanced antigen presentation, and stimulated an effective adaptive immune response, ultimately priming the tumor microenvironment (TME) together with the hypoxia alleviation and vessel normalization by Roxadustat.
I
n vivo results indicated that PFBT@Rox Lip nanoparticles promoted M1 polarization of tumor-associated macrophages, recruited more natural killer cells, and augmented infiltration of T cells, thereby leading to efficient photodynamic immunotherapy and potentiating the anti-primary and metastatic tumor efficacy of PD-1 antibody.
Collectively, photodynamic immunotherapy with PFBT@Rox Lip nanoparticles efficiently program TME through the induction of immunogenicity and oxygenation, and effectively suppress tumor growth through immunogenic cell death and enhanced anti-tumor immunity.
Keywords: Photodynamic immunotherapy, Hypoxia, Vascular normalization, Immunogenic cell death, Cancer therapy, Reactive oxygen species, Checkpoint blockades, Tumor microenvironment
Graphical Abstract: available at
https://ars.els-cdn.com/content/image/1-s2.0-S2211383525002394-ga1_lrg.jpg
A multifunctional nanosystem composed of a conjugated polymer (PFBT) and an EPO induce (Roxadustat) were designed and synthesized, realizing tumor photodynamic therapy with ROS production
via both type I/II reactions.
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The Journal of the
Institute of Materia Medica, the Chinese Academy of Medical Sciences and the
Chinese Pharmaceutical Association.
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https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/
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CiteScore: 24.3
Impact Factor: 14.6 (Top 6 journal in the category of Pharmacology and pharmacy)
JIF without self-citation: 13.8
ISSN 2211-3835
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Haitao Yuan, Xiaoxian Wang, Xin Sun, Di Gu, Jinan Guo, Wei Huang, Jingbo Ma, Chunjin Fu, Da Yin, Guohua Zeng, Ying Long, Jigang Wang, Zhijie Li, A photodynamic nanohybrid system reverses hypoxia and augment anti-primary and metastatic tumor efficacy of immunotherapy, Acta Pharmaceutica Sinica B, Volume 15, Issue 6, 2025, Pages 3243-3258, ISSN 2211-3835,
https://doi.org/10.1016/j.apsb.2025.04.007