A New Vaccine Candidate Strain of Coxsackievirus B5 Selected on the Basis of its Biological Properties
en-GBde-DEes-ESfr-FR

A New Vaccine Candidate Strain of Coxsackievirus B5 Selected on the Basis of its Biological Properties

01/07/2025 Compuscript Ltd


https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2025-0004
Announcing a new article publication for Zoonoses journal. Evidence indicates that coxsackievirus B5 (CVB5) can cause meningitis, and hand, foot, and mouth disease (HFMD), and is associated with type 1 diabetes. No effective drug or vaccine is available for treating CVB5 infections or controlling outbreaks.
The Vero-cell-adapted vaccine candidate strain KM299-L05 underwent comprehensive phylogenetic analysis, sequence alignment, assessment of virulence in BALB/c mice, Vero cell acclimation, three successive rounds of plaque purification, preparation of experimental vaccines, and immunogenicity evaluation.
KM299-L05 was the most virulent strain in BALB/c mice. Its infectious titer reached 108.0 CCID50/mL in Vero cells, and it belonged to the Chinese epidemic genotype C3. An inactivated CVB5 vaccine derived from the KM299-L05 strain produced neutralizing antibodies with a titer range from 1:384 to 1:768 against a variety of clinical CVB5 isolates, particularly the prototype strain. Maternal antibodies fully protected all examined suckling BALB/c mice against lethal challenge.
Although the study was limited to neonatal mice, our findings suggested that the KM299-L05 strain has potential as a novel CVB5 vaccine candidate in China, and provide a rationale for the development of a CVB5 vaccine.
VEEV was detected annually in 23.4% (128/548) of the cases, while EEEV appeared intermittently (1.5% [8/548]).
# # # # # #
Zoonoses is fully open access journal for research scientists, physicians, veterinarians, and public health professionals working on diverse disciplinaries of zoonotic diseases. Please visit https://zoonoses-journal.org/ to learn more about the journal.

Zoonoses is now open for submissions; articles can be submitted online at https://mc04.manuscriptcentral.com/zoonoses
There are no author submission or article processing fees.

Editorial Board: https://zoonoses-journal.org/index.php/editorial-board/

Zoonoses is available on ScienceOpen (https://www.scienceopen.com/search#collection/839df240-327f-47dd-b636-9b728dff9700).

Follow Zoonoses on Twitter @ZoonosesJ; Facebook (https://www.facebook.com/Zoonoses-Journal-100462755574114 ) and LinkedIn (https://www.linkedin.com/company/zoonoses/)

eISSN 2737-7474
ISSN 2737-7466
# # # # # #
Yuhan Liu, Zhaoyang Chu and Ming Zhang et al. A New Vaccine Candidate Strain of Coxsackievirus B5 Selected on the Basis of its Biological Properties. Zoonoses. 2025. Vol. 5(1). DOI: 10.15212/ZOONOSES-2025-0004
Yuhan Liu, Zhaoyang Chu and Ming Zhang et al. A New Vaccine Candidate Strain of Coxsackievirus B5 Selected on the Basis of its Biological Properties. Zoonoses. 2025. Vol. 5(1). DOI: 10.15212/ZOONOSES-2025-0004
01/07/2025 Compuscript Ltd
Regions: Europe, Ireland, Asia, China
Keywords: Health, Medical

Disclaimer: AlphaGalileo is not responsible for the accuracy of content posted to AlphaGalileo by contributing institutions or for the use of any information through the AlphaGalileo system.

Testimonials

For well over a decade, in my capacity as a researcher, broadcaster, and producer, I have relied heavily on Alphagalileo.
All of my work trips have been planned around stories that I've found on this site.
The under embargo section allows us to plan ahead and the news releases enable us to find key experts.
Going through the tailored daily updates is the best way to start the day. It's such a critical service for me and many of my colleagues.
Koula Bouloukos, Senior manager, Editorial & Production Underknown
We have used AlphaGalileo since its foundation but frankly we need it more than ever now to ensure our research news is heard across Europe, Asia and North America. As one of the UK’s leading research universities we want to continue to work with other outstanding researchers in Europe. AlphaGalileo helps us to continue to bring our research story to them and the rest of the world.
Peter Dunn, Director of Press and Media Relations at the University of Warwick
AlphaGalileo has helped us more than double our reach at SciDev.Net. The service has enabled our journalists around the world to reach the mainstream media with articles about the impact of science on people in low- and middle-income countries, leading to big increases in the number of SciDev.Net articles that have been republished.
Ben Deighton, SciDevNet

We Work Closely With...


  • e
  • The Research Council of Norway
  • SciDevNet
  • Swiss National Science Foundation
  • iesResearch
Copyright 2025 by AlphaGalileo Terms Of Use Privacy Statement