Combating Multi-drug Resistant Mycobacterium Species by Efflux Pump Inhibitors: Contemporary Trends
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Combating Multi-drug Resistant Mycobacterium Species by Efflux Pump Inhibitors: Contemporary Trends

03/06/2025 Compuscript Ltd
https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2025-0034
Announcing a new article publication for BIO Integration journal. Tuberculosis (TB) is caused by Mycobacterium tuberculosis (M.tb) complex (MTBC), which includes M.tb as one of the causative bacteria. In contrast, non-tuberculous mycobacteria (NTM) refers to Mycobacterium spp. that do not cause TB or leprosy (MTBC spp., M. leprae, and M. lepromatosis). Mycobacterium spp. are responsible for the deadliest infections and remain a significant challenge in diagnosis and treatment. Mycobacterium spp. have developed multiple complementary mechanisms to defend against antibiotics. Specifically, the mechanisms include modifying the drug target sites, enzymatically inactivating the drugs, and lowering intracellular antibiotic concentrations by overexpressing efflux pumps. These adaptations contribute to the emergence of multi-drug resistant pathogens. This review provides an overview of antibiotic resistance in Mycobacterium spp. with a focus on several key factors, such as enzyme-mediated antibiotic deactivation, gene expression, biofilm formation, and the role of efflux pumps. A critical objective of this review includes Mycobacterium efflux pumps, the significant role in antibiotic resistance, and compounds that act against these efflux pumps.
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BIO Integration is fully open access journal which will allow for the rapid dissemination of multidisciplinary views driving the progress of modern medicine.

As part of its mandate to help bring interesting work and knowledge from around the world to a wider audience, BIOI will actively support authors through open access publishing and through waiving author fees in its first years. Also, publication support for authors whose first language is not English will be offered in areas such as manuscript development, English language editing and artwork assistance.

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Please visit www.bio-integration.org to learn more about the journal.
Editorial Board: https://bio-integration.org/editorial-board/

BIOI is available on the IngentaConnect platform (https://www.ingentaconnect.com/content/cscript/bioi) and at the BIO Integration website (www.bio-integration.org).

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There are no author submission or article processing fees.

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ISSN 2712-0074
eISSN 2712-0082

Gautam Kumar, Priya Mondal and Amit Kadam et al. Combating Multi-drug Resistant Mycobacterium Species by Efflux Pump Inhibitors: Contemporary Trends. BIOI. 2025. Vol. 6(1). DOI: 10.15212/bioi-2025-0034
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Gautam Kumar, Priya Mondal and Amit Kadam et al. Combating Multi-drug Resistant Mycobacterium Species by Efflux Pump Inhibitors: Contemporary Trends. BIOI. 2025. Vol. 6(1). DOI: 10.15212/bioi-2025-0034
03/06/2025 Compuscript Ltd
Regions: Europe, Ireland
Keywords: Health, Medical

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