On the trail of a new medicine to treat multiple diseases
en-GBde-DEes-ESfr-FR

On the trail of a new medicine to treat multiple diseases


New research at NTNU (the Norwegian University of Science and Technology) is so promising that a European investor is funding researchers to the tune of EUR 1.8 million to further develop their findings.

This is the first time a Norwegian development project has received support from this fund.

It all started with two chemists, Bård Helge Hoff and Eirik Sundby. For several years they have been working on developing molecules with very special properties. These molecules are inhibitors that slow down the activity of proteins in the body that control processes in the cells.

In recent years, their goal has been to make molecules that inhibit the activity of a protein called CSF1R. This protein controls the formation of cells that play a key role in the development of disorders like osteoporosis, cancer and inflammatory diseases.

The research team has faced trial and error along the way, but most of all a lot of careful work. The chemists in the research group have created close to 700 finished compounds, each of which has been examined for bioactivity.

Thomas Ihle Aarhus, a PhD candidate, has been central to this work. Other students have also supported the team, and eventually Professor Geir Bjørkøy also came on board.

“We’ve had some revelations along the way, but most of our work has involved systematics and patience,” says Sundby.

“We needed to whittle the 700 compounds we’ve made down to just a handful. Fortunately, we found some smart ways to weed out the less relevant substances so we could concentrate on the ones that hold the most promise,” he says.

Raw deal in fight against big pharma companies

“The international competition to develop drugs to inhibit this protein is fierce, and it’s a pretty raw deal when a small research group goes head-to-head with big drug companies, says Gaute Brede, project manager at NTNU Technology Transfer Office (TTO).

“We wouldn’t have aroused the interest of the KAHN-I fund without support from the Research Council of Norway in the form of optimization funds,” says Brede.

Developing a new drug can cost billions. Conducting clinical trials, where new drugs are tested on humans, is not the least of the expense.

The goal of the interdisciplinary research group is therefore not to create a fully developed drug, but to get far enough in developing the special molecules that a major drug company will buy the patent.

“It’ll be highly relevant for a pharmaceutical company to take over the work on the project when we get to the point where our molecule shows good effects on two different animal models,” Sundby says. “We’re shooting to be there within 2 years.”

A lot has to happen during those two years. TTO therefore offered their support, including helping the group get in touch with the Lead Discovery Center (LDC) in Dortmund. This connection will enable the research group to make maximum headway in developing the key molecules at the core of the promising drug.

LDC is a company that supports and further develops universities' innovation projects in drug development. They have the necessary infrastructure and networks that the project needs to move forward.

Promising results

Following promising preclinical results in a mouse model conducted at the University of Edinburgh, the candidate drugs will now be tested for osteoporosis in an animal model. This phase will take place in collaboration with Unni Syversen, a professor at St. Olavs Hospital.

The encouraging results achieved by the researchers so far led the European KAHN-I fund to approve an application from TTO to invest EUR 1.8 million in the project. The funds are enabling the researchers to get that much closer to developing the new drug.

“We’ve chosen to concentrate on osteoporosis for now, partly because St. Olav's hospital has excellent knowledge about this disease model, but later we’ll test the newly developed molecules on other disease models as well, including brain cancer,” says Brede.

Attached files
  • One of several hundred compounds created in search of the right molecule. Photo: Kim Ramberghaug, NTNU
  • Norwegian University of Science and Technology (NTNU) chemists Bård Helge Hoff (left) and Eirik Sundby have been working on developing the main ingredient in a potential new drug for several years. Photo: Kim Ramberghaug, NTNU
Regions: Europe, European Union and Organisations, Norway
Keywords: Health, Grants & new facilities, Medical, Science, Chemistry, Grants & new facilities, Life Sciences

Testimonials

For well over a decade, in my capacity as a researcher, broadcaster, and producer, I have relied heavily on Alphagalileo.
All of my work trips have been planned around stories that I've found on this site.
The under embargo section allows us to plan ahead and the news releases enable us to find key experts.
Going through the tailored daily updates is the best way to start the day. It's such a critical service for me and many of my colleagues.
Koula Bouloukos, Senior manager, Editorial & Production Underknown
We have used AlphaGalileo since its foundation but frankly we need it more than ever now to ensure our research news is heard across Europe, Asia and North America. As one of the UK’s leading research universities we want to continue to work with other outstanding researchers in Europe. AlphaGalileo helps us to continue to bring our research story to them and the rest of the world.
Peter Dunn, Director of Press and Media Relations at the University of Warwick
AlphaGalileo has helped us more than double our reach at SciDev.Net. The service has enabled our journalists around the world to reach the mainstream media with articles about the impact of science on people in low- and middle-income countries, leading to big increases in the number of SciDev.Net articles that have been republished.
Ben Deighton, SciDevNet

We Work Closely With...


  • BBC
  • The Times
  • National Geographic
  • The University of Edinburgh
  • University of Cambridge
Copyright 2022 by AlphaGalileo Terms Of Use Privacy Statement