Acta Pharmaceutica Sinica B Volume 11, Issue 4 Publishes

12/05/2021 Compuscript Ltd
https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/11/issue/4
Special Issue: The Biological Fate of Drug Nanocarriers

This special issue includes seven review and nine research articles from some leading scientists in the field that further the discussion on subtopics ofinvivofate of drug nanocarriers.

Guest Editors: Wei Wu, Professor, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China; Tonglei Li, Professor, Department of Industrial & Physical Pharmacy, Purdue University, West Lafayette, IN, USA; Ying Zheng, Professor, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
The Journal of theInstitute of Materia Medica, the Chinese Academy of Medical Sciencesand theChinese Pharmaceutical Association, Acta Pharmaceutica Sinica B (APSB) is a monthly journal, in English, which publishes significant original research articles, rapid communications and high quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Featured papers in this issue are:
Intracellular uptake of nanocrystals: Probing with aggregation-induced emission of fluorescence and kinetic modelling by authors Jifen Zhang, Clairissa D. Corpstein and Tonglei Li, (https://doi.org/10.1016/j.apsb.2020.09.017). Nanocrystals of tetrakis (4-hydroxyphenyl) ethylene (THPE) were incubated with KB cells and the intracellular uptake was characterized by confocal microscopy and flow cytometry based on aggregation-induced emission property of THPE, as well as quantitative analyses of THPE. The intracellular dissolution kinetics model was established to further understand the cellular absorption mechanism of nanocrystals.
Impact of particle size and pH on protein corona formation of solid lipid nanoparticles: A proof-of-concept study by authors Wenhao Wang, Zhengwei Huang, Yanbei Li, Wenhua Wang, Jiayu Shi, Fangqin Fu, Ying Huang, Xin Pan and Chuanbin Wu (https://doi.org/10.1016/j.apsb.2020.10.023). Different protein corona formation phenomena were shown in solid lipid nanoparticles (SLNS) with the various size and medium pH. The biological effect and the underlying interaction mechanisms were studied to provide a systematic perspective.
Invivodissolution of poorly water-soluble drugs: Proof of concept based on fluorescence bioimaging by authors Yinqian Yang, Yongjiu Lv, Chengying Shen, Tingting Shi, Haisheng He, Jianping Qi, Xiaochun Dong, Weili Zhao, Yi Lu, and Wei Wu (https://doi.org/10.1016/j.apsb.2020.08.002 Authenticinvitroinvivocorrelation should be established betweeninvitrodissolution andinvivodissolution which however has never been determined accurately. This study provides proof of concept ofinvivodissolution based on live imaging of fluorescently hybridized crystals of a model poorly water-soluble drug fenofibrate.
Other articles published in the issue include:

Reviews
Innate and adaptive immune responses toward nanomedicines
Iara Maíra de Oliveira Vian, Sabrina Roussel, Joan Defrên, Eliana Martins Lim, Frédéric Barabé, Nicolas Bertrand
https://doi.org/10.1016/j.apsb.2021.02.022
Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles
Anan Yaghmur, Huiling Mu
https://doi.org/10.1016/j.apsb.2021.02.013
Effect of physicochemical properties on in vivo fate of nanoparticle-based cancer immunotherapies
Yongchao Wang, Jinjin Wang, Dandan Zhu, Yufei Wang, Guangchao Qing, Yuxuan Zhang, Xiaoxuan Liu, Xing-Jie Liang
https://doi.org/10.1016/j.apsb.2021.03.007
Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers
Samrat Mazumdar, Deepak Chitkar, Anupama Mittal
https://doi.org/10.1016/j.apsb.2021.02.019
Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies
Cláudia Pina Costa, João Nuno Moreira, José Manuel Sousa Lobo, Ana Catarina Silva
https://doi.org/10.1016/j.apsb.2021.02.012
Biological drug and drug delivery-mediated immunotherapy
Qingqing Xiao, Xiaotong Li, Yi Li, Zhenfeng Wu, Chenjie Xu, Zhongjian Chen, Wei Ha
https://doi.org/10.1016/j.apsb.2020.12.018
The role of caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems
Canyu Yang, Bing He, Wenbing Dai, Hua Zhang, Ying Zheng, Xueqing Wang, Qiang Zhang
https://doi.org/10.1016/j.apsb.2020.11.020
Original Articles
The contribution of absorption of integral nanocrystals to enhancement of oral bioavailability of quercetin
Baode Shen, Chengying Shen, Weifeng Zhu, Hailong Yuan
https://doi.org/10.1016/j.apsb.2021.02.015
In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions
Ana L. Martínez-López, Carlos J. González-Navarro, Paula Aranaz, José L. Vizmanos, Juan M. Irachea
https://doi.org/10.1016/j.apsb.2021.02.020
The biological fate of the polymer nanocarrier material monomethoxy poly(ethylene glycol)-block-poly(,l-lactic acid) in rat
Xiangjun Meng, Zhi Zhang, Jin Tong, Hui Sun, John Paul Fawcett, Jingkai Gu
https://doi.org/10.1016/j.apsb.2021.02.018
Gastrointestinal lipolysis and trans-epithelial transport of SMEDDS via oral route
Fei Xia, Zhongjian Chen, Quangang Zhu, Jianping Qi, Xiaochun Dong, Weili Zhao, Wei Wu, Yi Lu
https://doi.org/10.1016/j.apsb.2021.03.006
Intracellular uptake of nanocrystals: Probing with aggregation-induced emission of fluorescence and kinetic modeling
Jifen Zhang, Clairissa D. Corpstein, Tonglei Li
https://doi.org/10.1016/j.apsb.2020.09.017
Impact of particle size and pH on protein corona formation of solid lipid nanoparticles: A proof-of-concept study
Wenhao Wang, Zhengwei Huang, Yanbei Li, Wenhua Wang, Jiayu Shi, Fangqin Fu, Ying Huang, Xin Pan, Chuanbin Wu
https://doi.org/10.1016/j.apsb.2020.10.023
Uptake and trafficking of different sized PLGA nanoparticles by dendritic cells in imiquimod-induced psoriasis-like mice model
Zibei Lin, Long Xi, Shaokui Chen, Jinsong Tao, Yan Wang, Xin Chen, Ping Li, Zhenping Wang, Ying Zheng
https://doi.org/10.1016/j.apsb.2020.11.008
Short Communication
Intracellular aggregation of peptide-reprogrammed small molecule nanoassemblies enhances cancer chemotherapy and combinatorial immunotherapy
Jinrong Peng, Yao Xiao, Qian Yang, Qingya Liu, Yu Chen, Kun Shi, Ying Hao, Ruxia Han, Zhiyong Qian
https://doi.org/10.1016/j.apsb.2020.06.013
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