A new horizon for vibrational circular dichroism spectroscopy

29/05/2020 Ehime University
Vibrational circular dichroism (VCD) spectroscopy is an extension of circular dichroism spectroscopy into the infrared and near-infrared regions where vibrational transitions occur in the ground electronic state of a molecule. The method offers the advantage of studying the chiroptical properties of a wide range of molecules in non-crystalline states.

However, due to the weakness of the signals, one measurement requires several hours to yield reliable results. Accordingly, its target was limited to a stable molecule in a solution. To overcome this difficulty, our group applied the VCD method to supramolecular systems. In this article, we report a new horizon for VCD spectroscopy.

Solid state and time-step VCD methods were developed in determining the mechanism of chirality amplification from the microscopic to supramolecular scales. The VCD signals were enhanced in the following three cases: (i) chiral gels with hundreds of molecules arranged in stereoregularity, (ii) chiral metal complexes with low-lying excited states in the IR region, and (iii) a molecular pair interacting stereoselectively on a solid surface. Finally, we describe an on-going project involving the construction of a multi-dimensional VCD system.

Full bibliographic information

A new horizon for vibrational circular dichroism spectroscopy: a challenge for supramolecular chirality, Hisako Sato, DOI: 10.1039/D0CP00713G 2020, 22(15), 7671-7679, April 21
Attached files
  • Time-step VCD measured monitoring in situ the progress of chirality amplification from microscopic to supramolecular scales. [©ROYAL SOCIETY OF CHEMISTRY]

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