Excess Weight During Pre-School Linked to Higher Bone Fracture Risk

09/04/2020 Wiley
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Pre-school children who are overweight or obese have a higher risk of bone fractures during childhood than normal weight pre-schoolers, according to a study published in theJournal of Bone and Mineral Research.

The study included 466,997 children with weight and height measurements at age 4 years who were followed for a median of 4.9 years.

Fractures occurred in 9.20% of underweight, 10.06% of normal weight, 11.28% of overweight, and 13.05% of obese children. Compared with normal weight, overweight and obesity were linked with 42% and 74% higher risks of lower limb fractures, respectively, and a 10% and 19% higher risk of upper limb fractures, respectively.

“In a cohort of almost half a million children from Catalonia, Spain, we have found a strong association between pre-school overweight/obesity and the risk of fracture during childhood. More research is needed to further understand the mechanisms underlying this correlation” said senior author Daniel Prieto-Alhambra, PhD, of the University of Oxford, in the UK.

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Lane, J.C., Butler, K.L., Poveda‐Marina, J.L., Martinez‐Laguna, D., Reyes, C., de Bont, J., Javaid, M.K., Logue, J., Compston, J.E., Cooper, C., Duarte‐Salles, T., Furniss, D. and Prieto‐Alhambra, D. (2020), Preschool Obesity Is Associated With an Increased Risk of Childhood Fracture: A Longitudinal Cohort Study of 466,997 Children and Up to 11 Years of Follow‐up in Catalonia, Spain. JBMR. doi:10.1002/jbmr.3984

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