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No defects found in reproductive ability of male mice returning from short stay in space

10/10/2019 Osaka University

Male mice raised in space using specially developed cages were returned safely to Earth. The sperm production/fertilizing ability of the mice were normal and the reproduction ability of the offspring were not affected by their parents’ stay in outer space. The findings on the effects of the environment in space on the male reproductive system will contribute to the accumulation of basic knowledge for humankind to expand the range of its activity to space.

A team of researchers led by Professor Ikawa Masahito from the Research Institute for Microbial Diseases of Osaka University, in a joint research project with the University of Tsukuba and the Japan Aerospace Exploration Agency (JAXA), raised 12 male mice in the Japanese Experiment Module “Kibo” on the International Space Station (ISS) for 35 days, transporting them back safely from space. They revealed the world’s first findings that male mice sent to outer space retained their reproductive ability after their return. Their research results were published in Scientific Reports.

The human body is affected by gravity changes, radiation, and psychological stress during a stay in outer space. Technical challenges, such as a lack of adequate animal housing facilities, prevented researchers from raising experimental mammals in space and returning them to Earth. Thus, the effect of a stay in outer space on reproductive organs and fertility was not well understood.

This project team developed a habitat cage unit (HCU) capable of being installed in the Centrifuge-equipped Biological Experiment Facility (CBEF) on the ISS. The mice were placed under artificial gravity or microgravity (by centrifugation). After their return to Earth, they were compared with a “ground control” raised on the ground for the same 35-day period. (Fig.1)

The joint team found that:
1. The sperm production ability and the sperm fertilizing ability of the mice returned to Earth were normal, compared to the ground control and,
2. Offspring of the mice sent to outer space was healthy and there were no effects on their reproduction ability from their parents’ stay in outer space. (Fig. 2)

Prof. Ikawa says, “Because technological advances and the entry of private enterprises to space tourism have lowered the per person trip cost, the era where people can easily go to outer space is coming. Further analyses are necessary to examine the long-term effects of the environment in space on the male reproductive system; however, our research results will contribute to the accumulation of basic knowledge for humankind to expand the range of its activity to space.”

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The article “Male mice, caged in the International Space Station for 35 days, sire healthy offspring” was published in Scientific Reports at DOI: https://doi.org/10.1038/s41598-019-50128-w
Title: Male mice, caged in the International Space Station for 35 days, sire healthy offspring
Journal: Scientific Reports
Authors: Takafumi Matsumura, Taichi Noda, Musafumi Muratani, Risa Okada, Mutsumi Yamane, Ayako Isotani, Takashi Kudo, Satoru Takahashi, Masahito Ikawa
DOI: 10.1038/s41598-019-50128-w
Funded by: Japan Society for the Promotion of Science, Japan Agency for Medical Research and Development, Takeda Science Foundation, Japan Aerospace Exploration Agency, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Attached files
  • Fig.1. Overview of this study
  • Fig.2. Sperm morphology from mice housed in Kibo (A), and the offspring from fertilized eggs obtained by in vitro fertilization (B). GC: ground control, AG: artificial gravity (1G), MG: microgravity (0G)
10/10/2019 Osaka University
Regions: Asia, Japan
Keywords: Science, Space Science, Life Sciences

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