Genome sequencing of two Red Sea bacteria highlights their potential as industrial workhorses.
Analyses of two bacterial strains in the Red Sea show they are enriched with gene clusters with potential to activate the synthesis of a wide range of industrially useful compounds, from novel antibiotics, anticancer agents and pigments to those useful for crop protection and the food industry.
Bacteria are a rich resource for bioactive chemical compounds and Magbubah Essack, of KAUST’sComputational Bioscience Research Center, explains that bacterial strains able to withstand the Red Sea’s highly saline, warm waters were anticipated to produce sturdy enzymes suited for industrial applications.
The team sequenced the genomes of twoBacillusspecies:B. paralicheniformisBac48 collected from mangrove mud andB. paralicheniformisBac84 collected from a microbial mat in the Rabigh Harbor Lagoon on Saudi Arabia’s west coast. These two were compared with the documented genomes of three otherB. paralicheniformisand nineB. licheniformisstrains. The Red Sea strains had a higher number of gene clusters associated with bioactive compound synthesis compared to the otherBacillusstrains.
The team also report the first use of a computer program to identify a gene cluster in strains of theB. paralicheniformisspecies, in this caseB. paralicheniformisBac48, called trans-acyltransferase nonribosomal peptide synthetase/polyketide synthase, which is associated with the production of a specific group of compounds.
“The findings affirm the premise that the Red Sea is a metabolically unique environment worthy of exploration for efficient microbes that can be used as biotechnological hosts,” says computational bioscientist Ghofran Othoum, the first author of the study. “Also, our computational exploratory approach showed the strength of computer modeling methods in applications that require ranking biological systems for biotechnological use.”
Future research will focus on seeking out which bioactive compounds are produced by the two Red Sea strains.