https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/16/issue/10
Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.
APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Articles of interest in this issue include:
Post CDK4/6 inhibitors: Novel targeted combinations based on SERDs in HR+/HER2– advanced breast cancer by Yan Wang, Jiayu Wang and Binghe Xu (https://www.sciencedirect.com/science/article/pii/S2211383526005113). Mechanism-informed SERD-based combinations counter post-CDK4/6i resistance in HR⁺/HER2⁻ advanced breast cancer through ER degradation and co-targeting of ESR1-driven ER reactivation, RTK-mediated bypass signaling, PI3K/AKT/mTOR–MAPK activation, and CDK2/CDK7 cell-cycle escape.
Antibody peptide conjugates as multifunctional therapeutics: Mechanisms, challenges, and prospects by Fei Xie, Lianqi Liu, Qi Cheng, Dian Xiao, Xinbo Zhou and Song Li (https://www.sciencedirect.com/science/article/pii/S2211383526005101) Antibody peptide conjugates (APCs) represent a newly emerging class of targeted biotherapeutics that combine the precise delivery capabilities of antibodies with the diverse biological activities of peptides.
Unnatural amino acid-based miniPROTACs enable efficient oncoprotein degradation by Jianchao Zhang, Xiao Chen, Congli Chen, Fengming Li et al. (https://www.sciencedirect.com/science/article/pii/S2211383526001279) Minimalist PROTACs using unnatural amino acids as degrons achieve efficient, selective degradation of oncogenic targets.
In vivo fate mapping of a paclitaxel-loaded polymeric micelle and its components by Luyao Yu, Yingxia Guo, Tonghe Liu, Yunlong Sheng et al. (https://www.sciencedirect.com/science/article/pii/S2211383526001188) In vivo tracing of paclitaxel and its polymer carrier elucidates the pharmacokinetic behavior of the polymeric micelle.
Other articles include:

Unleashing the Potential of Nanodrugs: Advances in Disease Management

Review
Intelligent nano delivery systems: Classification, stimuli-responsive mechanisms, and therapeutic applications in critical illnesses
Mengxin Zhao, Baofeng Guo, Quanhao Wang, Mei Yang, ... Ling Zhang


Original article
Selenium nanozymes effectively treat rheumatoid arthritis by specifically activating selenoproteins to block oxidative damage and cGAS–STING signaling pathway
Yang Yang, Yonglan Yang, Wenguan Huang, Xiaoyan Zhong, ... Xu Chen


Reviews
Antibody‒cell conjugates: A novel “off-the-shelf” modality bridging ADCs and CAR-T for cancer immunotherapy
Yifei Dai, Yujia Xie, Xiaojuan Ma, Dong Zhang, ... Weijie Qiang

The interaction of flavonoids, alkaloids, and terpenoids with the major drug transporters in the organic anion transporting polypeptide and organic anion transporter families
Zichong Li, Xuyang Wang, Chaomin Pan, Mei Hong

Molecular mechanisms, crosstalk and therapeutic potential of novel acylation modifications in cardiovascular and cerebrovascular diseases
Wanchun Li, Weile Ye, Jiaojiao Wang, Zhiping Liu

Emerging insights into PPARα′s role in lean metabolic dysfunction-associated steatotic liver disease: Implications for targeted therapies
Yafei Yang, Furong Zhang, Zhuang Peng, Yafei Wu, ... Shufang Na

Advances and perspectives of next-generation antitumor antibody-based modalities: Structural innovation and target-driven strategies
Liangjie Sun, Baixin Xu, Shuhang Wang, Ning Li

Application of computational methods in the drug discovery and development of Alzheimer's disease
Qianqian Zhang, Xiaoqing Gong, Huanxiang Liu, Xiaojun Yao

Mapping neutrophil membrane bioactivity to therapeutic interfaces: Biology, disease targeting, and activity-guided biomimetic therapy
Qingqing Yang, Mingjing Leng, Wenbi Jiang, Huan Yang, ... Xiaohui Li

Lysosome-targeted nanomaterials for advanced cancer therapy: Overcoming resistance, activating immunity and amplifying therapeutic synergy
Hongmei Zheng, Haipeng Cheng, Namei Li, Jing Cai

Modulating macrophage efferocytosis: Drug delivery strategies for enhancement, mimicry, and inhibition
Zhihua Liu, Jiahui Wu, Jiayan Lyu, Zhou Zhou, Yuan Huang


Clinical trial
Association between the use of traditional Chinese medicine patterns as an inclusion criterion and statistical significance in primary outcomes of randomized placebo-controlled trials of Chinese herbal formulas
Zhijun Bu, Meirong Song, Chen Chen, Xinyi Shi, ... Yugen Chen


Original articles
Antihypertensive drug-induced liver injury is rare, but strongly associated with HLA-B∗35:01
Lily Dara, Paola Nicoletti, Chaudry Nasir Majeed, Andrew Dellinger, ... Herbert L. Bonkovsky

Reprogramming gut microbiota and targeting CXCL1: The multifaceted mechanism of PLP1 in ameliorating alcohol-induced liver disease
Zhu Yang, Qiuyue Lv, Qiangbao Xu, Yan Chen, ... Jun Han

Molecular mechanisms of YZG-331 ameliorated insomnia based on the gut microbiota–drug interaction
Hengtong Zuo, Qinglan Guo, Bin Zhao, Jinyue Lu, ... Yan Wang

BD2-selective BRD4 inhibitor ZX29 mitigates myocardial ischemia–reperfusion injury via BRD4–YY1–NCOA4 axis disruption and ferroptosis inhibition
Zeyu Li, Meixiu Xin, Zhongkai Wu, Jing Lu, ... Peiqing Liu

A mechanistic quantitative systems pharmacology framework enriched by multiscale data enables model-informed translational development of mesenchymal stem cell therapy in lupus nephritis
Sujie Zhang, Qixiang Zhang, Dandan Wang, Zichun Li, ... Chen Zhao

Therapeutic targeting of the PRMT6/FOXK1 axis restores lipid homeostasis and ameliorates hepatic steatosis and steatohepatitis in mice
Yang Sun, Tao Chen, Lei Zhang, Jinlin Duan, ... Yonglong Zhang

Identification and characterization of a non-nucleotide RdRp allosteric inhibitor with pan-coronavirus protection
Qian Guo, Xiaomeng Yang, Zhihao Zhao, Jian-Piao Cai, ... Shuofeng Yuan

Discovery of a small molecule RIOK1 inhibitor CINS-1 against colorectal cancer via disrupting ribosomal biosynthesis
Ying Jiang, Chuan Huang, Fang Wu, Guolong Liu, ... Jiajie Zhang

Machine learning-driven discovery of aniline phenylacetate derivatives as LasR-targeted biofilm inhibitors against Pseudomonas aeruginosa infections
Yujing Huang, Haoming Chen, Jiamin Wu, Xiaojie Huang, ... Junxia Zheng

Identification of FDA-approved IMPDH inhibitors boosting the broad-spectrum antiviral potential of ribavirin through depleting cellular GTP pool
Qiangyun Ai, Huina Hu, Kaixiong Ma, Qingxing Wang, ... Shaobo Wang

Discovery of a potent covalent inhibitor for the treatment of sepsis targeting DNAJC9: Identification of a druggable target for inflammation
Xingjun Li, Tao Yang, Hui Huang, Yalan Ma, ... Hong Liu

In vivo validation of intramolecular bivalent glues targeting PSMA reveals potent and tissue-selective BRD4 degradation in prostate cancer
Deqin Cai, Chunrong Li, Malick Bio Idrissou, Nina J. Hawkins, ... Weiping Tang

Oral artificial microbio-vaccine triggers synergistic immunogenic cell death induction and tumor microenvironment remodeling for liver cancer therapy
Qian Cheng, Siyao Li, Lu Deng, Li Xiong, ... Jinming Zhang

Stimulate-and-retain hydrogel strategy integrating oncolytic virus and oxaliplatin for dual ICD-inducing antitumor immunity
Dan Zhang, Anxian Chen, Haimeng Huang, Wenjing Li, ... Xiaowei Zeng

Double coordination-driven Fe–DOX synergy enhances ferroptosis and immunogenic cancer therapy
Gaeun Ma, Yun-Hwa Jeong, Yeonsu Ryu, Jae-Hyeon Lee, ... Jooho Park

Remodeling macrophage efferocytosis and phenotype via targeted nanoimmunotherapy for atherosclerosis
Zhongshan He, Yaoyao Luo, Yongjiang Li, Shuping Yang, ... Xiangrong Song

Effects of anti-PEG antibodies on extravascular transport of stealth liposome: A study on interspecies differences
Ercan Wu, Tianhao Ding, Yifei Yu, Mengyuan Liu, ... Changyou Zhan

Lysosomal membrane damage repair and acidification impairment restoration triggered by smart lipid nanoparticles for Alzheimer's disease treatment
Jiaqing Yin, Wei Lv, Wei Zhao, Zhenwei Ding, ... Hongliang Xin

The role of cardiomyocytic FOXP3 and extracellular vesicle-mediated delivery of FOXP3 into cardiomyocytes for treating pathological cardiac hypertrophy
Jiahui Hong, Ping Tan, Yao Yuan, Zikun Lin, ... Haigang Zhang

Ultra-sensitive detection of receptor binding domain of SARS-CoV-2 based on artificial intelligence assisted antibody selection and antibody‒nucleic acid conjugation signal amplification
Jiatong Liu, Wenfan Chen, Xiufeng Li, Yuanyuan Luo, ... Sheng Cai


Highlight
Learn from nature, surpass nature: Bionic immune cell engineering—A new paradigm for unlocking the dual “delivery-activation” code in cancer therapy
Guanyi Chen, Baohu Li, Shenghua Gao, Jinfei Yang, Peng Zhan


Commentaries
miniPROTACs: Bridging PROTACs and molecular glues with a new degron alphabet
Jin Wang

Illuminating the black box: Mapping the fates of polymeric micelle drug carriers in vivo
Xinxin Ding
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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
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CiteScore: 24.4
Impact Factor: 14.6 (Top 8 journal in the category of Pharmacology and pharmacy)
JIF without self-citation: 14.0

ISSN 2211-3835
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