https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2025-0058
Announcing a new publication for
Acta Materia Medica journal. Despite therapeutic advances, long-term psoriasis management remains challenged by cost, immunogenicity, and administration barriers. Although the anti-inflammatory properties of avicularin (AL) are recognized, its direct targeting of IL-17RA and its therapeutic efficacy in psoriasis remain unreported. The authors of this article established the efficacy of
Euphorbia humifusa Willd. (EH) in a psoriasis mouse model, then used an integrated strategy combining network pharmacology, RNA-seq, and surface plasmon resonance-mass spectrometry (SPR-MS) to assess its pharmacodynamic material basis. This systematic approach identified the IL-17 pathway as the primary mechanism, and IL-6, CXCL10, and IL-17RA as key targets. On the basis of these key targets, SPR-MS screened seven candidate compounds from EH, among which AL was confirmed as a key IL-17RA-targeting bioactive compound. Subsequent validation demonstrated that AL dose-dependently ameliorated psoriatic lesions and downregulated key IL-17 pathway effectors, including IL-17RA, IL-6, and CXCL10 (
p < 0.05). Direct binding between AL and IL-17RA was subsequently confirmed through bio-layer interferometry, SPR-MS re-screening, and molecular docking. These findings not only establish AL as a promising oral IL-17RA-targeted agent but also delineate a robust strategy that may aid in the systematic discovery of active natural compounds.
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eISSN 2737-7946
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Qianqian Zhou, Zhe Wang and Yuanxiang Wang et al. Network pharmacology-guided discovery of avicularin from Euphorbia humifusa Willd. targeting IL-17 signaling in psoriasis.
Acta Materia Medica. 2026. Vol. 5(1):88-112. DOI: 10.15212/AMM-2025-0058