https://doi.org/10.1016/j.apsb.2025.05.018
This new article publication from
Acta Pharmaceutica Sinica B, discusses how melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1.
A major obstacle in type 2 diabetes mellitus (T2DM) is sleep fragmentation (SF), which negatively affects testicular function. However, the underlying mechanisms remain to be elucidated. This study demonstrated that SF induces testicular damage through a mechanism involving lipid metabolism, specifically mediated by melatonin (MEL) receptor 1a (MT1). T2DM mice with SF intervention displayed several deleterious phenotypes such as apoptosis, deregulated lipid metabolism, and impaired testicular function. Unexpectedly, sleep recovery (SR) for 2 consecutive weeks could not completely abrogate SF's detrimental effects on lipid deposition and testicular function. Interestingly, MEL and MT1 agonist 2-iodomelatonin (2IM) effectively improved lipid homeostasis, highlighting MEL/2IM as a promising therapeutic drug for SF-trigged testicular damage. Mechanistically, MEL and 2IM activated FGFR1 and sequentially restrained the crosstalk and physical interaction between TAB1 and TAK1, which ultimately suppressed the phosphorylation of TAK1 to block lipid deposition and cell apoptosis caused by SF. The ameliorating effect of MEL/2IM was overtly nullified in
Fgfr1 knockout (
Fgfr1-KO+/–) diabetic mice. Meanwhile, testicular-specific overexpression of
Tak1 abolished the protective effect of FGF1
mut on diabetic mouse testis. These findings offer valuable insights into the molecular mechanisms underlying the testicular pathogenesis associated with SF and propose a novel therapeutic approach for addressing male infertility in T2DM.
Keywords: Sleep fragmentation, Testicular injury, Melatonin receptor, Lipid metabolism, FGFR1, TAB1, TAK1, T2DM
Graphical Abstract: available at
https://ars.els-cdn.com/content/image/1-s2.0-S2211383525003247-ga1_lrg.jpg
Sleep fragmentation in T2DM impairs the testes by disrupting lipid metabolism. Melatonin and its agonist protect by activating FGFR1 to inhibit TAK1 phosphorylation, reducing lipid deposition and apoptosis.
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The Journal of the
Institute of Materia Medica, the Chinese Academy of Medical Sciences and the
Chinese Pharmaceutical Association.
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CiteScore: 24.3
Impact Factor: 14.6 (Top 6 journal in the category of Pharmacology and pharmacy)
JIF without self-citation: 13.8
ISSN 2211-3835
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Xiaohui Zhang, Xinyu Tang, Ting Gao, Yuanfang Guo, Guangping Lu, Qingbo Liu, Jiahao Li, Jie Wang, Mingrui Liu, Dongmei Zhang, Yufeng Tang, Junlian Gu, Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1, Acta Pharmaceutica Sinica B, Volume 15, Issue 7, 2025, Pages 3591-3610, ISSN 2211-3835,
https://doi.org/10.1016/j.apsb.2025.05.018