Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most common chronic liver disease in children and adolescents, closely mirroring the global rise in childhood obesity. The condition can lead to long-term health problems, yet many affected children may not be identified early. Simple, low-cost screening tools such as waist-to-height ratio (WHtR) could help detect those at risk, but their reliability across different ethnic groups and genetic backgrounds has remained uncertain. Genetic factors are known to influence susceptibility to MASLD, but it has been unclear whether this inherited risk changes how well simple body measurements perform in screening.
The findings, on June 3, 2026, in the , come from a large collaborative team led by researchers at Peking University in China. The study combined Chinese schoolchildren and U.S. NHANES data to test WHtR across populations and genetic backgrounds. Genetic variants differed only modestly, and higher genetic risk slightly lowered theoretical thresholds but left WHtR largely stable. In National Health and Nutrition Examination Survey (NHANES), WHtR ≥ 0.48 performed well across most ethnic groups, except “other Hispanic” participants. Genetic risk scores added little, suggesting a simple tape measure may suffice for initial screening.
The findings, published (DOI: 10.1007/s12519-026-01084-9) in the World Journal of Pediatrics on August 28, 2026, come from a large collaborative team led by researchers at Peking University in China. It combined data from Chinese schoolchildren and the U.S. NHANES to test WHtR across populations and genetic backgrounds. Genetic variants differed only modestly, and higher genetic risk slightly lowered theoretical thresholds but left WHtR largely stable. In NHANES, WHtR ≥ 0.48 performed well across most ethnic groups, except for “other Hispanic” participants. Adding genetic risk scores (GRS) provided little additional benefit, suggesting a simple tape measure may suffice for initial screening.
The findings challenge the notion that genetic information is necessary for effective mass screening. The study found generally small differences at MASLD-related loci, with the greatest divergence in individuals of African ancestry and moderate divergence in South Asian populations. More importantly, while a higher GRS theoretically lowers the optimal screening cutoff value for various indices, this effect was most dramatic for complex markers like the Visceral Adiposity Index (VAI) but remarkably stable for WHtR. This suggests that WHtR remains a reliable screening measure even among children with different levels of genetic susceptibility. The team validated this in the diverse NHANES cohort, where using a WHtR threshold of 0.48 continued to identify children at risk with strong performance across most ethnic groups, including non-Hispanic White, Black, and Asian participants, although the “other Hispanic” group was a notable exception. Importantly, adding GRS provided only limited additional benefit, suggesting that a simple tape measure may be sufficient for initial screening and that complex genetic profiling may not be necessary to identify children at risk.
The authors said they were particularly struck by how consistently WHtR performed. "Our goal was to find a screening tool that works for everyone, not just those with access to advanced labs," they explained. "The fact that this simple ratio maintains its accuracy across diverse genetic backgrounds is very encouraging. While genetic testing has its place, we found that incorporating it into screening models offered very little real-world benefit for initial detection. A simple tape measure, combined with a clear cutoff, can help healthcare workers everywhere identify at-risk children and intervene early."
The study may have important public health implications. In high-income settings where genetic testing is available, the findings could help refine risk stratification and support earlier, more personalized interventions. In low- and middle-income countries, where genetic testing is often unavailable, WHtR could serve as a practical frontline screening tool for primary care physicians, school health programs, and community health workers. By offering a simple and scalable approach to early detection, WHtR may help identify children who need further evaluation and timely follow-up, potentially reducing the long-term burden of pediatric MASLD. However, WHtR is a screening measure, not a diagnostic test, and positive findings require clinical confirmation.
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References
DOI
10.1007/s12519-026-01084-9
Original Source URL
https://doi.org/10.1007/s12519-026-01084-9
Funding information
This study was supported by grants from Capital’s Funds for Health Improvement and Research (2022–1G-4251 to SY), National Natural Science Foundation of China (82273654 to SY), Zhejiang Provincial Natural Science Foundation of China (LTGY24H260007 to LL), Medical Health Science and Technology Project of Zhejiang Province (2025KY1315 to ZPP), Cyrus Tang Foundation for Young Scholar 2022 (2022-B126 to WH), and China Scholarship Council (202406010179 to LYF; 202406010169 to WYX).
About World Journal of Pediatrics
World Journal of Pediatrics (WJP) is an international, peer-reviewed academic journal dedicated to advancing pediatric medicine and child health. Published monthly, WJP publishes original research, reviews, and special reports covering all aspects of pediatrics. It welcomes contributions from pediatricians and researchers worldwide, focusing on the latest developments in pediatric clinical practice, pediatric surgery, preventive child healthcare, pharmacology, stomatology, and biomedicine, as well as basic and experimental sciences. The journal provides a global platform for academic exchange and dissemination of medical research findings. WJP currently has an Impact Factor of 7.3 and a CiteScore of 8.5.