Instead of applying ointment and attaching a bandage, a ‘smart patch that regulates treatment intensity on its own just by being attached’ has appeared. Our university's research team has developed a ‘self-regulating OLED wound healing patch’ that combines light and drugs to pull up the wound recovery speed by about twice. It is expected to develop into an intelligent treatment technology where light regulates drug release according to the patient's condition in the future.
KAIST announced on the 13th that a research team led by Professor Kyung Cheol Choi of the School of Electrical Engineering, together with Dr. Daekyung Sung of the Korea Institute of Ceramic Engineering and Technology (President Jong-seok Yoon) and Professor Chan-Su Park's team at Chungbuk National University (Acting President Yu-sik Park), developed a ‘self-regulating wound healing patch’ technology that combines Organic Light Emitting Diodes (OLED) and a Drug Delivery System (DDS).
Ointments can cause side effects when overused, and Photobiomodulation (PBM)* treatment, which helps cell regeneration using light, also had limitations in that its effect decreased if the appropriate amount was exceeded. *PBM (Photobiomodulation): A non-invasive treatment method that promotes the recovery of cells and tissues using low-intensity light.
The research team focused on solving the limitations of existing treatment methods, which make it difficult to appropriately regulate treatment intensity. The core of this research is that ‘light regulates the medicine.’ When light is applied, Reactive Oxygen Species (ROS) are generated in the body, and this substance plays a role in stimulating nanoparticles so that drugs are released.
In other words, the amount of reactive oxygen species generated varies according to the intensity of light, and the amount of drug release is naturally regulated accordingly. When light is applied, cell regeneration is promoted, and at the same time, the ROS generated at this time acts as a ‘switch’ so that the drug is automatically released only as much as necessary. It is an ‘intelligent treatment method’ in which the treatment maintains its optimal level on its own even if a person does not regulate it separately. Simply put, it is a ‘self-regulating treatment patch’ where the medicine automatically comes out in an appropriate amount according to the intensity of the light when it is shone.
The research team produced a 630-nanometer (nm) wavelength OLED patch that closely adheres to the skin. This patch was designed to deliver light evenly to induce cell regeneration while releasing an appropriate amount of antioxidant drugs, such as Centella asiatica (commonly known as tiger grass) extract, a plant-derived ingredient well known for its skin regeneration effects.
In addition, it was produced in a wearable form that perfectly adheres to the curves of the skin to reduce light energy loss, and it maintains a temperature of about 31 degrees Celsius even during long-term use, allowing it to be used safely without the risk of low-temperature burns. Stability, maintaining performance for more than 400 hours, was also confirmed, securing the possibility of application to actual medical devices.
The effect was confirmed through experiments. In skin cell experiments, ‘combined treatment’ using light and drugs together showed faster recovery than single treatment. In mouse experiments, the wound recovery rate was 67% as of the 14th day of treatment, recording a healing speed about twice as fast as that of the control group (35%). The quality of healing was also significantly improved, such as skin thickness and barrier protein formation recovering to normal levels.
Professor Kyung Cheol Choi stated, “This research is an example of expanding OLED-based light treatment beyond the level of simply applying it to the role of regulating the treatment, and into a combined treatment platform where drug release is automatically regulated according to the wound status. We plan to develop it into an intelligent treatment technology that can be applied to various wounds and diseases and reacts on its own according to the patient's body condition.”
In this research, Hyejeong Yeon, a doctoral student at the KAIST School of Electrical Engineering, participated as the first author. It was published online in the international academic journal ‘Materials Horizons’ last January and was selected as the Front Cover Paper in March.
※ Paper title: A self-regulating wearable OLED patch for accelerated wound healing via photobiomodulation-triggered drug delivery, DOI: https://doi.org/10.1039/D5MH02129D (Authors: Hyejeong Yeon, Sohyeon Yu, Minhyeok Lee, Sangwoo Kim, Yongjin Park, Hye-Ryung Choi, Won Il Choi, Chang-Hun Huh, Yongmin Jeon, Chan-Su Park, Daekyung Sung, and Kyung Cheol Choi)
This research was conducted with the support of the Future Discovery Convergence Science and Technology Development Program (2021M3C1C3097646) carried out through the National Research Foundation of Korea (NRF) of the Ministry of Science and ICT.