As global men’s health research rapidly advances toward precision and intelligence, multiple articles in UroPrecision have garnered sustained attention and high readership.
In this issue, we have selected 9 high-impact articles covering topics such as artificial intelligence, minimally invasive prostate treatments, sexual and regenerative medicine, and reproductive endocrinology and male infertility. Together, they highlight the current focal points in clinical and translational research.
These articles not only reflect the genuine interests of our readers but also embody the shared trends in urology and andrology today, including technological innovation, evidence-based medicine, and the optimization of clinical decision-making.
Topic 1: Artificial Intelligence and Digital Health in Men
Shaping the future of men’s sexual health: How artificial intelligence can assist in the management and treatment of erectile dysfunction
Main text: Artificial Intelligence (AI) is progressively being integrated into the entire process of diagnosing and treating erectile dysfunction (ED), encompassing virtual consultations, intraoperative assistance, drug development, and postoperative rehabilitation management. This article systematically reviews the current applications of AI in ED management and delves into the ethical, privacy, and practical challenges encountered during its clinical implementation, emphasizing the need to strike a balance between innovation and regulation.
DOI: 10.1002/uro2.31
Artificial intelligence and varicocelectomy: A new horizon for patient management? A narrative review
Main text: Varicocele is one of the most common reversible causes of male infertility. In recent years, artificial intelligence and machine learning models based on big data have been employed to predict the probability of postoperative semen parameter improvement, demonstrating predictive capabilities that may surpass those of traditional models. This article systematically reviews relevant research advancements and explores the potential applications and limitations of AI in personalized patient management.
DOI: 10.1002/uro2.70003
Topic 2: Innovations in Minimally Invasive Prostate Therapies
Development of a high-power blue diode laser for precision vaporization of prostate tissue for the surgical management of benign prostatic hyperplasia
Main text: This article explores the cutting-edge applications of high-power blue laser in the treatment of benign prostatic hyperplasia (BPH). By leveraging its high absorption efficiency for hemoglobin, blue laser significantly enhances tissue vaporization while ensuring effective hemostasis and minimal thermal damage. Preliminary clinical data suggest its potential to further refine minimally invasive surgical strategies for BPH.
DOI: 10.1002/uro2.30
Sexual dysfunction after Rezum therapy for benign prostatic hyperplasia: A scoping review for the current insights and findings
Main text: Rezum water vapor therapy has garnered attention for its minimally invasive nature and functional preservation benefits. This scoping review analyzed 15 studies involving 2425 patients and found that the therapy has no significant negative impact on erectile and ejaculatory function overall, with some studies even indicating a trend toward improvement. These findings provide substantial evidence-based support for clinical counseling and patient decision-making.
DOI: 10.1002/uro2.93
The impact of UroLift implants on prostate MRI imaging
Main text: UroLift implants may generate artifacts on multiparametric MRI of the prostate, particularly affecting the transition zone and diffusion-weighted imaging, which could interfere with the detection of prostate cancer and the evaluation of targeted biopsies. This article summarizes existing research and clinical experience to discuss the potential impact of these artifacts on imaging diagnosis and localized treatment decision-making.
DOI: 10.1002/uro2.112
Topic 3: Sexual Medicine and Regenerative Therapies
Current insights and future directions in Peyronie’s disease management: A narrative review
Main text: Peyronie’s disease (PD) is a condition characterized by fibrotic plaques and curvature deformity of the penis. This article systematically reviews treatment strategies for both the acute and stable phases, while summarizing research advancements in plaque formation mechanisms, imaging evaluation, regenerative therapies, and surgical technique optimization. It emphasizes the importance of personalized and precision management.
DOI: 10.1002/uro2.104
Intracavernosal platelet-rich plasma therapy for erectile dysfunction: Current evidence and future directions
Main text: Platelet-rich plasma (PRP), as a regenerative treatment strategy, has garnered widespread attention in the management of erectile dysfunction (ED). This article reviews existing clinical studies, noting significant heterogeneity in PRP preparation methods, dosage regimens, and follow-up protocols. While preliminary results are promising, high-quality, long-term follow-up studies are still required to clarify its definitive clinical role.
DOI: 10.1002/uro2.70004
Topic 4: Reproductive Endocrinology and Male Infertility
Testosterone and men's health: An in-depth exploration of their relationship
Main text: Testosterone plays a crucial physiological role throughout a man’s life, and abnormal testosterone levels are closely associated with hypogonadism, metabolic syndrome, cardiovascular disease, and sexual dysfunction. This article explores the evaluation and personalized management strategies for testosterone-related disorders from the perspective of biomarkers and precision medicine.
DOI: 10.1002/uro2.115
Emerging trends in the management of non-obstructive azoospermia
Main text: Non-obstructive azoospermia (NOA) accounts for approximately 10% of male infertility cases. This article focuses on the potential applications of whole-exome sequencing (WES) and serum/seminal biomarkers in preoperative assessment for sperm retrieval via microsurgery, exploring future directions for accurately predicting sperm retrieval success rates.
DOI: 10.1002/uro2.70002