https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2025-0095
Announcing a new article publication for
BIO Integration journal. Transdermal drug delivery (TDD) offers a non-invasive alternative to conventional administration routes, yet the efficacy of TDD is constrained by the impermeable stratum corneum (SC) of the skin, particularly for macromolecules exceeding 500 Da. While microneedle technology addresses this barrier by creating micro-scale channels, the limited penetration depth of microneedles restricts drug delivery to superficial epidermal layers. This review highlights the transformative potential of combining ultrasound and microneedles for enhanced TDD, which synergistically integrate physical disruption and energy-driven permeation enhancement. Unlike material-based or charge/magnetism-dependent strategies, ultrasound leverages multifactorial mechanisms (mechanical stress, cavitation, and thermal effects) to propel drugs through microneedle-generated pathways into deeper tissues. The ultrasound-microneedle (US-MN) system enables spatiotemporally controlled drug release with sonochemical/piezoelectric effects expanding applications in precision medicine. This article critically evaluates the underlying mechanisms, technological innovations, and clinical translation challenges of the US-MN emphasizing the versatility for macromolecules and precision medicine. By bridging mechanisms with translational gaps, this work provides a roadmap for optimizing the US-MN platform, offering researchers actionable strategies to advance TDD for chronic diseases, vaccines, and targeted therapies.
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BIO Integration is fully open access journal which will allow for the rapid dissemination of multidisciplinary views driving the progress of modern medicine.
As part of its mandate to help bring interesting work and knowledge from around the world to a wider audience,
BIOI will actively support authors through open access publishing and through waiving author fees in its first years. Also, publication support for authors whose first language is not English will be offered in areas such as manuscript development, English language editing and artwork assistance.
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ISSN 2712-0074
eISSN 2712-0082
Lingling Lei, Wangrui Peng and Jianfeng Cai et al. Combined Ultrasound and Microneedle for Enhanced Transdermal Delivery: Synergistic Mechanisms and Therapeutic Advances.
BIOI. 2025. Vol. 6(1). DOI: 10.15212/bioi-2025-0095
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