https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2025-0036
Announcing a new article publication for
BIO Integration journal. Natural killer cell adoptive therapy is a novel immunotherapy strategy for the treatment of multiple refractory tumors, including ovarian cancer.
However, natural killer cells’ anti-tumor effectiveness is limited by their viability and cytotoxicity. This study suggests that ultrasound irradiation improves the therapeutic effects of natural killer cells on ovarian cancer through an unclear mechanism. The Wnt/β-catenin signaling pathway is a complex protein network system associated with the maturation and function of natural killer cells.
To reveal the precise mechanism underlying the effects of ultrasound on natural killer cells, the expression of Wnt/β-catenin signaling pathway proteins were measured before and after ultrasound irradiation. The expression of therapeutic factors secreted by natural killer cells increased after ultrasound irradiation. Therefore, this study provides an additional strategy for optimizing the therapeutic efficiency of natural killer cells.
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BIO Integration is fully open access journal which will allow for the rapid dissemination of multidisciplinary views driving the progress of modern medicine.
As part of its mandate to help bring interesting work and knowledge from around the world to a wider audience,
BIOI will actively support authors through open access publishing and through waiving author fees in its first years. Also, publication support for authors whose first language is not English will be offered in areas such as manuscript development, English language editing and artwork assistance.
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https://www.scienceopen.com/search#collection/55f45bac-fd64-431c-9fe7-50fd6a7f8781).
Submissions may be made using
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ISSN 2712-0074
eISSN 2712-0082
Renjie Feng, Ao Gu and Gökhan Zengin et al. Low-intensity Pulsed Ultrasound Enhances NK Cell Adoptive Therapy by Modulating the Wnt/β-catenin Signaling Pathway.
BIOI. 2025. Vol. 6(1). DOI: 10.15212/bioi-2025-0036
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