https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/15/issue/6
Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.
APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Articles of interest in this issue include:

Editorial Special Column: Nanomedicines for tumor microenvironment modulation by Huile Gao, Feihu Wang and Yang Shi, (https://doi.org/10.1016/j.apsb.2025.05.027). Nanomedicine is a powerful tool for disease microenvironment modulation and disease treatment. Deep understanding of the function of microenvironment in disease development may provide new targets for nanomedicine design and disease treatment.
Nanomedicine-driven tumor glucose metabolic reprogramming for enhanced cancer immunotherapy by Chenwei Jiang, Minglu Tang, Yun Su and colleagues, (https://doi.org/10.1016/j.apsb.2025.04.002). Glucose metabolism modulating nanomedicines (GMMNs) precisely target tumor cells, respond to the tumor microenvironment, enable multi-drug co-delivery, and facilitate combination therapies, thereby effectively correcting aberrant glucose metabolism, reshaping the immunosuppressive microenvironment, and ultimately improving the efficacy of cancer immunotherapy.
Silencing PTPN2 with nanoparticle-delivered small interfering RNA remodels tumor microenvironment to sensitize immunotherapy in hepatocellular carcinoma by Fu Wang, Haoyu You, Huahua Liu and colleagues, (https://doi.org/10.1016/j.apsb.2025.03.015). Glucose metabolism modulating nanomedicines (GMMNs) precisely target tumor cells, respond to the tumor microenvironment, enable multi-drug co-delivery, and facilitate combination therapies, thereby effectively correcting aberrant glucose metabolism, reshaping the immunosuppressive microenvironment, and ultimately improving the efficacy of cancer immunotherapy.
Linkage of circadian rhythm disruptions with Alzheimer's disease and therapeutic interventions by Kishore Madamanchi, Jianhua Zhang and Girish C. Melkani, (https://doi.org/10.1016/j.apsb.2025.04.011). Circadian rhythm disruption (CRD) accelerates aging, neurodegeneration, and gut dysbiosis, creating a feedback loop that worsens Alzheimer's disease (AD). AD further disrupts circadian rhythms, fueling cognitive decline and metabolic imbalance. Time-restricted feeding (TRF) realigns circadian rhythms, restores gut microbiome balance, and enhances cognitive function, offering a non-invasive strategy to slow AD progression.
Other articles include:

Special Column: Nanomedicines for Tumor Microenvironment Modulation
Reviews
Advancements in CRISPR/Cas systems for disease treatment
Yangsong Xu, Hao Le, Qinjie Wu, Ning Wang, Changyang Gong

Original articles
Self-degradable “gemini-like” ionizable lipid-mediated delivery of siRNA for subcellular-specific gene therapy of hepatic diseases
Qiu Wang, Bin Wan, Yao Feng, Zimeng Yang, ... Qikun Jiang

Nose-to-brain delivery of targeted lipid nanoparticles as two-pronged β-amyloid nanoscavenger for Alzheimer's disease therapy
Yanyan Xu, Xiangtong Ye, Yanfeng Du, Wenqin Yang, ... Weiwei Zhang

Submicron-sized superantigen biomimetic liposomes with highly efficient pulmonary accumulation to remodel local immune microenvironment for cancer chemoimmunotherapy
Bochuan Yuan, Feng Zhang, Qiucheng Yan, Wanmei Wang, ... Fei Xie

Reviews
Obesity–cancer axis crosstalk: Molecular insights and therapeutic approaches
Ahmed Rakib, Md Abdullah Al Mamun, Mousumi Mandal, Priti Sinha, Udai P. Singh

Structures and functions of the MICOS: Pathogenesis and therapeutic implications in Alzheimer's disease
Zihan Wang, Kaige Zhang, Minghao Huang, Dehao Shang, ... Xinwen Zhang

Unravelling the target landscape of tranylcypromines for new drug discovery
Yihui Song, Junbiao Chang, Bin Yu

Tools
Phenotypic screening uncovered anti-myocardial fibrosis candidates using a novel 3D myocardial tissue under hypoxia
Jingyu Wang, Xiangning Liu, Rongxin Zhu, Ying Sun, ... Wei Wang





Original articles
Neurokinin 1 receptor inhibition alleviated mitochondrial dysfunction via restoring purine nucleotide cycle disorder driven by substance P in acute pancreatitis
Chenxia Han, Lu Li, Lin Bai, Yaling Wu, ... Qing Xia

SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts
Tongzhu Jin, Huiying Gao, Yuquan Wang, Zhiwei Ning, ... Haihai Liang

RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce lung cancer metastasis
Wen Zhang, Yulin Peng, Meirong Zhou, Lei Qian, ... Xiaochi Ma

An anti-complement homogeneous polysaccharide from Houttuynia cordata ameliorates acute pneumonia with H1N1 and MRSA coinfection through rectifying Treg/Th17 imbalance in the gut–lung axis and NLRP3 inflammasome activation
Xinxing Li, Wenxin Ding, Yan Lu, Haiyan Zhu, ... Daofeng Chen

ALKBH3-regulated m1A of ALDOA potentiates glycolysis and doxorubicin resistance of triple negative breast cancer cells
Yuhua Deng, Zhiyan Chen, Peixian Chen, Yaming Xiong, ... Dan Zhou

Ablation of macrophage transcriptional factor FoxO1 protects against ischemia–reperfusion injury-induced acute kidney injury
Yao He, Xue Yang, Chenyu Zhang, Min Deng, ... Lu Tie

The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition
Lei Wang, Shanchun Ge, Ye Zhang, Deqin Feng, ... Chaofeng Zhang

Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis
Bin Liu, Wen-Zhe Deng, Wen-Hua Hu, Rong-Xi Lu, ... Rong-Rong He

Design, synthesis and biological evaluation of a novel class of indazole-containing compounds with potent anti-influenza activities targeting the PA-PB1 interface
Yun-Sang Tang, Chao Zhang, Jing Xu, Haibo Zhang, ... Pang-Chui Shaw

Discovery of papyifuran A as an unusual cembrane diterpenoid from Boswellia papyrifera resin reveals EEF2 as a potent new drug target for fibrosis of multiple organs
Madhu Babu Sura, Yeting Zhou, Jijun Li, Yongxian Cheng

Functional aptamer evolution-enabled elucidation of a melanoma migration-related bioactive epitope
Hong Xuan, Siqi Bian, Qinguo Liu, Jun Li, ... Liqin Zhang

Unveiling the metabolic fate of drugs through metabolic reaction-based molecular networking
Haodong Zhu, Xupeng Tong, Qi Wang, Aijing Li, ... Zhihong Yao

Targeting stem-property and vasculogenic mimicry for sensitizing paclitaxel therapy of triple-negative breast cancer by biomimetic codelivery
Siqi Wu, Qing Tang, Weifeng Fang, Zhe Sun, ... Yongzhuo Huang

A photodynamic nanohybrid system reverses hypoxia and augment anti-primary and metastatic tumor efficacy of immunotherapy
Haitao Yuan, Xiaoxian Wang, Xin Sun, Di Gu, ... Zhijie Li

Alginate lyase immobilized Chlamydomonas algae microrobots: minimally invasive therapy for biofilm penetration and eradication
Xiaoting Zhang, Huaan Li, Lu Liu, Yanzhen Song, ... Yingfeng Tu

A chemotherapy nano-booster unlocks wider therapeutic window for prostate cancer treatment
Rui Liao, Yuequan Wang, Ziqi Lin, Yuting Wang, ... Cong Luo

Tranexamic acid-fatty alcohol polyoxyethylene ether conjugation/PVA foam for venous sclerotherapy via vascular damage and inhibiting plasmin system
Jizhuang Ma, Keda Zhang, Wenhan Li, Yu Ding, ... Pingtian Ding

Pitavastatin-loaded procyanidins self-assembled nanoparticles alleviate advanced atherosclerosis via modulating macrophage efferocytosis and cholesterol efflux
Yizhou Wu, Hongyan Zhou, Hao Liu, Jiayao Hu, ... Bin Liu

Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines
Jing-Jing Chen, Ting Gong, Wei-Bo Wang, Tian-Jiao Chen, ... Ping Zhu

Letter to the Editor
Veronica anagallis-aquatica L. iridoid glycosides alleviate heart failure via metabolites homoveratrumic acid and 2-hydroxy-3,4-dimethoxybenzoic acid mediated by the gut microbiota
Manjiong Wang, Xiaobo Guo, Hanfang Liu, Xiao Li, ... Yixiang Xu

Highlights
PRIME, a temperature-guided language model revolutionizes protein engineering
Yuanxi Yu, Qianhui Wang, Yike Zou

Mechanism of Alzheimer's disease treatment by sound and light stimulation
Lixuan Ren, Xiwen Ma, Jianping Ye

Editorial
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy
Fan Jia, Siyuan Peng, Wenhao Wang, Xin Pan

Commentary
Unlocking the therapeutic potential of RNA splicing in lung fibrosis: Insights from the SRSF7–PKM axis
Bi-Sen Ding
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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
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CiteScore: 24.3
Impact Factor: 14.6 (Top 6 journal in the category of Pharmacology and pharmacy)
JIF without self-citation: 13.8

ISSN 2211-3835
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