https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2025-0008
Announcing a new publication for
Acta Materia Medica journal. Geroprotectors that delay aging have substantial potential for preventing and mitigating age-related diseases.
Natural products derived from traditional herbal medicines are promising candidates for geroprotector discovery, because of their multi-target mechanisms and preventive health benefits.
Through screening of 836 Chinese herbal medicine extracts, it was identified that the leaf extract of
Caryota maxima (
JM13001) significantly extended lifespan and healthspan in
Caenorhabditis elegans.
JM13001 increased total lipid content and upregulated mono-unsaturated fatty acids (MUFAs), which are known to contribute to longevity.
JM13001 exerted its effects through DAF-2 signaling, thereby promoting lipid accumulation and extending lifespan in nematodes.
Notably, the lifespan-extending effects of
JM13001 were abolished after the loss of key enzymes responsible for converting saturated fatty acids to MUFAs or after oleic acid supplementation; therefore, its geroprotective effects are dependent on MUFAs.
Chemical analysis revealed that
JM13001 contains flavonoids such as rutin, isoquercitrin, and kaempferol-3-O-rutinoside, among which rutin alone was sufficient to reproduce the anti-aging and lipid accumulation promotion effects of
JM13001 through DAF-2 signaling.
This study identifies a novel geroprotective herbal extract and its active ingredient, thereby providing insights into the anti-aging mechanisms of natural geroprotectors via MUFA metabolism regulation.
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eISSN 2737-7946
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Zhifan Mao, Haiyan Jiang and Lingyuan Bao et al. Caryota maxima leaf extract extends Caenorhabditis elegans lifespan by inducing mono-unsaturated fatty acid accumulation via DAF-2 signaling.
Acta Materia Medica. 2025. Vol. 4(3):493-506. DOI: 10.15212/AMM-2025-0008