A new review in Genes & Diseases highlights Piezo channels as important biological links between mechanical forces and the cellular processes that shape the face, move teeth and influence oral health. The article focuses on Piezo1 and Piezo2, mechanosensitive ion channels that convert physical forces into cellular signals throughout the craniofacial skeleton and periodontal tissues.

Mechanical stimulation plays a central role in both dentofacial deformities and their treatment. During orthodontic care, forces applied to teeth trigger carefully coordinated bone formation and resorption, allowing teeth to move into new positions. Piezo channels appear to be central to this response, helping cells detect mechanical pressure and translate it into biological activity.

Piezo1 has particularly broad functions in this process. It influences periodontal ligament cells, bone-forming cells, stem cells and immune cells, helping regulate the balance between osteogenesis and osteoclastogenesis. Activation of Piezo1 can initiate signalling pathways involved in cell differentiation, inflammation and bone remodelling. Piezo2, meanwhile, contributes to communication between sensory nerves and alveolar bone, providing another mechanism through which mechanical forces can influence tooth movement.

These channels may also be important in managing some of the major challenges associated with orthodontic treatment. Excessive mechanical loading and abnormal Piezo activity are linked with root resorption and may contribute to orthodontic pain. More precise control of Piezo activity could therefore offer ways to support efficient tooth movement while reducing unwanted effects.

Their importance extends beyond orthodontic tooth movement. Piezo channels are also implicated in conditions associated with dentofacial deformities, including temporomandibular joint osteoarthritis (TMJOA) and periodontitis. Excessive Piezo1 activation under abnormal mechanical loading can promote inflammatory responses and cartilage damage in the temporomandibular joint. In periodontal tissues, altered Piezo signalling may disturb the balance between bone formation, bone resorption and immune activity.

Future Piezo-targeted therapies could provide new opportunities for more precise orthodontic care. Potential approaches include selective channel activation or inhibition, locally delivered treatments and physical therapies designed around the channels’ responses to mechanical stimulation. By simultaneously influencing bone remodelling, inflammation and pain, Piezo channels could eventually help support faster, safer and more personalised treatment for patients with dentofacial deformities.
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Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis is placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.
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Reference
Jinhan Nie, Yi Zhang, Jun Ma, Min Hu, Huichuan Qi, Roles of Piezo channels in dentofacial deformity: Onset, orthodontic treatment, and associated diseases, Genes & Diseases, Volume 13, Issue 6, 2026, 102123, https://doi.org/10.1016/j.gendis.2026.102123

Funding
National Natural Science Foundation of China 82100956
Jilin Provincial Natural Science Foundation of China YDZJ202301ZYTS432
IOF Young Research Grant for HQ (China) IOF2023Y19