Potential therapeutic effect of stem cells on sensorineural hearing loss
en-GBde-DEes-ESfr-FR

Potential therapeutic effect of stem cells on sensorineural hearing loss

15.04.2026 Frontiers Journals
Sensorineural hearing loss (SNHL) remains a global health challenge with limited regenerative therapeutic options. This review delineates advancements in stem cell-based therapies, emphasizing their potential to restore auditory function through cellular regeneration and molecular modulation. Stem cells, including mesenchymal (MSCs), induced pluripotent (iPSCs), and embryonic stem cells (ESCs), exhibit multilineage differentiation and paracrine signaling capabilities, enabling hair cell (HC) regeneration, spiral ganglion neuron (SGN) repair, and inflammation modulation. Cochlear organoid models derived from stem cells have advanced mechanistic studies, though challenges persist in replicating cochlear-specific HC phenotypes. Exosomes, as nanoscale bioactive vesicles, demonstrate enhanced biocompatibility and barrier penetration, effectively mitigating oxidative stress, apoptosis, and aminoglycoside ototoxicity while promoting HC survival. Gene-editing technologies, notably CRISPR-Cas9 and adeno‐associated virus (AAV) gene delivery systems, synergize with stem cell platforms to correct pathogenic mutations and engineer therapeutic cells for targeted inner ear repair. Preclinical studies highlight MSC transplantation and exosome administration in improving auditory thresholds and neuronal morphology, yet clinical translation faces hurdles including delivery precision, immune responses, and scalability. Current limitations in replicating cochlear cytoarchitecture and standardizing differentiation protocols necessitate further exploration of combinatorial strategies, such as integrating stem cell therapy with cochlear implants or medicament delivery systems. Future research needs prioritize optimizing cell lineage specification, enhancing exosome targeting, and validating long-term safety to realize the transformative potential of regenerative medicine in SNHL treatment.
The work entitled “Potential therapeutic effect of stem cells on sensorineural hearing loss” was published in Biophysics Reports (ahead of print in 2026).
DOI: 10.52601/bpr.2025.240017
https://www.biophysics-reports.org/article/doi/10.52601/bpr.2025.240017
Angehängte Dokumente
  • Image: Illustration of stem cell-driven oto-regenerative prospect in hearing loss therapy. This figure was generated using FigDraw online platform (www.figdraw.com)
15.04.2026 Frontiers Journals
Regions: Asia, China
Keywords: Science, Life Sciences

Disclaimer: AlphaGalileo is not responsible for the accuracy of content posted to AlphaGalileo by contributing institutions or for the use of any information through the AlphaGalileo system.

Referenzen

We have used AlphaGalileo since its foundation but frankly we need it more than ever now to ensure our research news is heard across Europe, Asia and North America. As one of the UK’s leading research universities we want to continue to work with other outstanding researchers in Europe. AlphaGalileo helps us to continue to bring our research story to them and the rest of the world.
Peter Dunn, Director of Press and Media Relations at the University of Warwick
AlphaGalileo has helped us more than double our reach at SciDev.Net. The service has enabled our journalists around the world to reach the mainstream media with articles about the impact of science on people in low- and middle-income countries, leading to big increases in the number of SciDev.Net articles that have been republished.
Ben Deighton, SciDevNet
AlphaGalileo is a great source of global research news. I use it regularly.
Robert Lee Hotz, LA Times

Wir arbeiten eng zusammen mit...

  • The Research Council of Norway
  • SciDevNet
  • Swiss National Science Foundation
  • iesResearch
Copyright 2026 by DNN Corp Terms Of Use Privacy Statement