Prospective multicenter study finds Woven EndoBridge therapy safe and effective for unruptured wide-necked bifurcation aneurysms in Chinese patients

A prospective multicenter study reports that Woven EndoBridge intrasaccular therapy safely and effectively treats unruptured wide-necked bifurcation aneurysms, one of the most challenging brain aneurysm types to manage. The trial found high occlusion stability, low complication rates, and no retreatments or deaths at one year of follow-up. The findings support this minimally invasive option as a promising alternative to conventional techniques and expand evidence supporting its safe and effective use in a Chinese patient population.

Brain aneurysms are balloon-like bulges in blood vessels that can rupture, causing life-threatening hemorrhages. Wide-necked bifurcation aneurysms (WNBAs), occurring at arterial branch points, are particularly challenging to treat due to their complex anatomy. Conventional coiling or stent-assisted techniques may require long-term blood-thinning therapy and carry risks of thromboembolism or vessel damage. Seeking safer, less invasive options, researchers investigated the Woven EndoBridge (WEB) intrasaccular device, designed to sit entirely inside the aneurysm, disrupt blood flow, and promote clot formation without extending into the parent artery.

A research team led by Professor Hongqi Zhang from the Department of Neurosurgery at Xuanwu Hospital, Capital Medical University, Beijing, China and Professor Jianmin Liu from Neurovascular Center, Naval Medical University, Changhai Hospital, Shanghai, China, conducted a prospective multicenter observational study across eight Chinese hospitals between June 2017 and August 2019. The study enrolled 60 adult patients with unruptured WNBAs suitable for WEB implantation. Each patient underwent standardized imaging, procedural planning, and follow-up at 30 days, 6 months, and 1 year. The study was published in Volume 12 of the Chinese Neurosurgical Journal on January 20, 2026.

The WEB device, a braided nitinol mesh, was implanted using microcatheters and detached within the aneurysm sac. Its design may reduce reliance on dual antiplatelet therapy and the risk of thromboembolic complications compared with techniques requiring permanent intravascular implants. Procedural success was achieved in 98% of cases. At one-year follow-up, complete aneurysm occlusion was observed in 56% of patients, with adequate occlusion in 82%. No patients required retreatment, experienced aneurysm rupture, or died. Major adverse events occurred in only two patients (3.9%), both unrelated to the device. Functional independence, measured by modified Rankin scores, remained high throughout follow-up, with nearly all patients maintaining normal daily activities.

“These findings suggest that intrasaccular flow disruption can provide durable aneurysm occlusion rupture while minimizing risks associated with traditional techniques,” said Prof. Zhang. The study demonstrates that the WEB device can safely seal complex aneurysms with a high degree of stability over time, even in anatomically challenging locations such as the anterior communicating artery and middle cerebral artery bifurcations.

Beyond individual patient benefits, the findings support the broader evaluation and adoption of minimally invasive intrasaccular techniques for complex aneurysms. The results contribute important clinical data from a Chinese population and provide a foundation for future comparative studies and longer-term follow-up investigations.

Prof. Liu added, “Our results demonstrate that advanced endovascular technologies can be safely adopted across diverse populations, paving the way for international collaboration and future device innovation.” The study’s findings underscore the potential of WEB therapy to redefine how neurosurgeons’ approach one of the most challenging types of brain aneurysms, offering hope for safer, more effective, and widely accessible treatment.

While further research with larger cohorts and longer follow-up is needed, the current study confirms that the WEB device provides a reliable, safe, and effective alternative to conventional treatments for WNBAs, setting a foundation for future improvements in global neurovascular care.