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Key find for early bladder cancer treatment

23 May 2013 Lund University

Aggressive forms of bladder cancer involve the protein PODXL – a discovery that could hold the key to improved treatment, according to researchers at Lund University, Uppsala University and KTH in Sweden.

“With better knowledge of this protein, we can better determine a patient’s prognosis and
see who needs more aggressive treatment immediately and who can be given a
milder treatment without a risk to their life. We can see at an early stage
which patients are in the risk zone for cancer recurrence”, said Karolina Boman,
a doctoral student at the Division of Pathology at Lund University.

The study involved almost 500 men and women between the ages of 39 and 90. The patients with
tumours containing the protein podocalyxin-like, PODXL, had an increased risk
of a cancer recurrence or of dying of the disease within two years – even in
cases that were discovered early and only had superficial tumours.

“We have previously shown that the presence of this protein in the cell membrane of
patients with colorectal cancer increases the risk of recurrence or of dying of
the disease. Now we have seen the same thing in patients with bladder cancer.
The prognosis is poor even if the protein is only present in low
concentrations”, said Karolina Boman.

The researchers believe that the new findings about this protein could also be of
use for other forms of cancer.

“We can no doubt utilise this for example for pancreatic cancer, colon cancer and ovarian
cancer. It could also save society a lot of money, especially if in the future we
could see which tumours contain the protein using a simple urine test. That is
what we are going to look at now”, said Karolina Boman.

Attached files


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